![]() ![]() Therefore, we also welcome articles discussing the role of immune cells and cytokines for the ageing brain, as well as the role of inflammation in neuromuscular disorders associated with senescence. Over the last few decades, increasing evidence is implicating a role for the immune system in brain physiology and behaviour. We seek reviews, viewpoints, commentaries, or original research articles exploring the role of stress, mood disorders, and sensory systems during normal and premature immunosenescence. This topical collection will explore how complex neuroimmune interactions promote healthy and pathological ageing. Topical collection: Neuroimmunology and Ageing Such studies will provide important information on the clinical implications of differences in clonal mutational dynamics in diverse populations under different conditions. have now developed a new method to overcome this difficulty and present a longitudinal study tracking the nature and fate of clonal HSC expansions over a 16-year period covering late middle-age to old age. However, because of the complexity and cost of analytic methods such as whole-exome or genome sequencing, most investigations thus far have been cross-sectional, with all the limitations of such studies. It is clinically important because it is associated with an increased incidence of myeloid dysplasias that may become malignant, as well as cardiovascular disease. This phenomenon rarely occurs in younger people under 40, but is present in 10-20% of those over 70 and may even reach essentially 100% in the oldest old. ![]() This is an age-related expansion of a mutant hematopoietic stem cell (HSC) arbitrarily defined as >2% of the blood cells. Blood is an easily accessible tissue in which clonal hematopoiesis can be documented. Mutations accumulate in multiple tissues with age, but can be challenging to quantify. This condition would be covered in your policy if your pet has been symptom and treatment free for more than 2 years before the start date of your cover.Editors' pick: Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics If your pet was diagnosed with a luxating patella (a kneecap that 'pops out’) in one of their back legs before the start date of your cover, and the other leg is later diagnosed with the same issue, we would consider this to be a bilateral condition and as such, pre-existing to your policy.This condition would be covered in your policy if your cat has been symptom and treatment free for more than 2 years before the start date of your cover. If your cat was grooming themselves more than usual before the start date of your cover, and was later diagnosed with a skin condition, we'd consider this to be pre-existing.This condition would be covered in your policy if your dog has been symptom and treatment free for more than 2 years before the start date of your cover. If your dog showed signs of stiffness or limping prior to the start date of your cover, and was later diagnosed with arthritis, we’d consider this to be a pre-existing condition.Charities we support Charities we support. ![]()
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